In a nutshell The study evaluated the impact of consolidation radiotherapy (cRT) on patients with advanced Hodgkin lymphoma (HL) who had large nodal mass (LNM) and currently in complete metabolic response (CMR) after receiving ABVD chemotherapy. The authors found that cRT could be safely avoided in such patients. Some background CMR defines...
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In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation. The authors found that sorafenib maintenance therapy decreased the risks of relapse and mortality after HSCT in such...
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In a nutshell This study aimed to investigate if blinatumomab was an effective treatment in patients with minimal residual disease B-cell precursor acute lymphoblastic leukemia. This study concluded that complete minimal residual response during blinatumomab treatment can be a potentially...
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In a nutshell This study aimed to investigate the combination of low-dose decitabine, medium-dose cytarabine and umbilical cord blood infusion as a consolidation therapy for elderly patients with acute myeloid leukemia. This study concluded that this treatment combination was effective in these patients. Some...
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In a nutshell This study wanted to assess the effectiveness of using azacitidine (Vidaza) after chemotherapy to maintain response to treatment in patients with acute myeloid leukemia. Researchers found that azacitidine improves survival without disease in these patients. Some background Acute myeloid leukemia (AML) is a cancer of the immune...
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In a nutshell This article investigated the safety and effectiveness of high-dose therapy with autologous stem cell transplantation (HDT-ASCT) and maintenance treatment (treatment meant to keep cancer from coming back) with lenalidomide (Revlimid) for patients with multiple myeloma. The authors concluded that this therapy is safe...
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In a nutshell This study aimed to evaluate the effectiveness of nilotinib as a consolidation therapy for patients with chronic myeloid leukemia who had achieved a major response with imatinib. This study concluded that nilotinib led to safer, deeper responses in these patients. Some background Imatinib (Gleevec) is a tyrosine kinase inhibition (TKI)...
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In a nutshell This study aimed to identify the outcomes and prognostic factors following a stem cell transplant from a donor in adults with acute myeloid leukemia in their second complete remission (no sign of disease). The authors determined that this type of transplant was effective in these patients. Some background In adult patients with acute...
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In a nutshell This study looked at the effectiveness of mismatched donor stem cell transplantation (SCT) for treating children with high-risk relapse of acute lymphoblastic leukemia (ALL). Researchers found that mismatched donor SCT was useful but not as effective as matched donor SCT in children with high-risk ALL. Some background Acute lymphoblastic...
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In a nutshell This study investigated the long-term outcomes of patients with non-Hodgkin’s lymphoma (NHL) or multiple myeloma (MM) who received plerixafor (Mozobil) or placebo combined with G-CSF (granulocyte colony stimulating factor) before a stem cell transplant (SCT). This study concluded that adding plerixafor to G-CSF did not negatively...
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In a nutshell This study examined the healthcare usage of Hodgkin Lymphoma survivors. The authors concluded that survivors had increased healthcare usage up to 10 years after treatment. Some background Survivors of Hodgkin lymphoma (HL) sometimes experience late treatment effects. These include secondary lung cancer, secondary...
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