In a nutshell This study investigated the safety and effectiveness of switching to SB2 from infliximab (Remicade) in patients with rheumatoid arthritis. They found that switching to SB2 from infliximab was well tolerated and effective at reducing disease activity. Some background Rheumatoid arthritis (RA) is a chronic disease that causes...
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In a nutshell This study examined the long-term safety and effectiveness of abatacept (Orencia) and whether methotrexate (Trexall) enhances its effect. Some background Abatacept is a drug used to treat patients with rheumatoid arthritis (RA). It is generally given to patients in whom anti-tumor necrosis factor therapy has...
Read MoreIn a nutshell This study examined the frequency of gastrointestinal (digestive tract) events in at-risk rheumatic patients using non-steroidal anti-inflammatory drugs. Some background Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil) are used to relieve pain in patients with rheumatic diseases. However, they can also cause...
Read MoreIn a nutshell This study examined whether a combination of clinical and ultrasound assessments could identify rheumatoid arthritis patients suitable for a lower dose of anti-TNF alpha therapy. Some background Anti-TNF alpha therapy (Humira, Enbrel, Remicade and Cimzia) is used to treat patients who have a severe form of rheumatoid...
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In a nutshell This study examined the safety and effectiveness of switching from intravenous tocilizumab (Actemra) to subcutaneous. Some background Tocilizumab is a drug which prevents the immune system from attacking the joints in rheumatoid arthritis patients. It is given intravenously (injected into a vein by a healthcare...
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In a nutshell This study investigated whether doctors could predict the long term effectiveness of infliximab (Remicade) treatment for rheumatoid arthritis, based on early results at 3 months. Some background Rheumatoid arthritis is an autoimmune disease, caused by the immune system attacking healthy tissue. Blocking the immune system...
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In a nutshell This study examined the effects of withdrawing biologic drugs upon remission in established long-term RA patients. Some background Rheumatoid arthritis (RA) is an inflammatory disease affecting the joints, the connections between bones. The main focus of RA treatment is to reduce pain and inflammation, and to limit the amount of...
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