In a nutshell This study aimed to investigate the influence of the time of starting adjuvant chemotherapy on survival outcomes in different types of breast cancer. This study concluded that more aggressive breast cancers require early adjuvant chemotherapy. Some background Surgery to remove the tumor is a commonly used treatment method for...
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Long-term effects of stereotactic ablative radiotherapy for patients with NSCLC
In a nutshell The authors examined the long-term effects of stereotactic ablative radiotherapy (SABR) in treating patients with stage 1 non-small-cell lung cancer (NSCLC). They concluded that SABR is both safe and effective in the long-term. Some background SABR is a type of radiation used to treat inoperable early stage NSCLC. Studies have shown...
Read MoreSurgery to treat stage 1 non-small cell lung cancer
In a nutshell This trial examined different surgical techniques to treat early stage non-small-stage lung cancer. The authors concluded that there was no difference in effectiveness between three different surgical techniques for patients with early stage NSCLC. Some background Early-stage non-small cell lung cancer (NSCLC) is commonly...
Read MoreThe beneficial effects of trastuzumab on locoregional control in HER2-positive breast cancer patients.
In a nutshell This study investigated the effects of trastuzumab (Herceptin) on the locoregional control (management in the area in which it arose) of patients with HER2-positive breast cancer (HER2+BC) following radiotherapy (RT). Trastuzumab administered alongside RT was found to be associated with a significantly reduced rate of locoregional...
Read MoreIncidence of ovarian function recovery in women over 40 with chemotherapy induced amenorrhea
In a nutshell This study investigated ovarian function recovery (OFR) after chemotherapy-induced amenorrhea (absence of menstruation) in women aged 40-49 after 2 years of aromatase inhibitor (AI) therapy. The study concluded that a large number of women with chemotherapy-induced amenorrhea recover ovarian function during AI therapy. Some...
Read MoreComparing axillary lymph node ultrasound and fine needle aspiration in breast cancer
In a nutshell This study investigated whether patients with a suspicious axillary lymph node (ALN) but negative fine-needle aspiration result (FNA) can be considered as having node-negative disease (AUN). The study concluded that patients with suspicious ALN on ultrasound but negative FNA results can be treated as having node-negative disease. Some...
Read MoreLocalized surgery outcomes in early rectal cancer
In a nutshell This study investigated the outcomes of localized surgery following chemotherapy and radiation therapy (CRT) in rectal cancer. Researchers suggested that localized surgery should only be considered after a complete response to CRT. Some background Radical surgery or total mesorectal excision (TME; bowel and lymph nodes around...
Read MoreSurgical margins are associated with local recurrences in melanoma
In a nutshell This study investigated the factors associated with local recurrence (LR; when the cancer comes back) in melanoma patients. Researchers suggested that a surgical margin of greater than or equal to 1cm reduces the risk of LR. Some background Most patients with a primary melanoma (stage 1) have a tumor that is thin (equal to 1 mm or...
Read MoreTargeted therapy for elderly patients with non-small cell lung cancer
In a nutshell This analysis aimed to assess whether targeted therapy drugs gefatinib and erlotinib are safer and more effective to treat non-small-cell lung cancer (NSCLC) in elderly patients, compared to chemotherapy and radiation therapies. The authors concluded that these two targeted therapy drugs are effective and safe to treat lung cancer in...
Read MoreSearching for patients with stage 1 non-small cell lung cancer that cannot be surgically removed to undergo radiation therapy
In a nutshell This phase 3 trial aims to compare the effectiveness of stereotactic body radiotherapy with conventional radiotherapy in patients with early stage non-small-cell lung cancer (NSCLC) that cannot undergo surgery for medical reasons. The main outcome of the trial will be absence of local recurrence (whether the cancer has come back at or...
Read MoreLDH as an early predictor of cancer survival
In a nutshell This study investigated the relationship between lactate dehydrogenase (LDH) levels and cancer-specific survival. Researchers concluded that LDH can be used as an early indicator of cancer outcomes. Some background Early cancer detection methods have significantly improved cancer survival rates. There is increasing evidence to...
Read MoreLDH as an early predictor of cancer survival
In a nutshell This study investigated the relationship between lactate dehydrogenase (LDH) levels and cancer-specific survival. Researchers concluded that LDH can be used as an early indicator of cancer outcomes. Some background Early cancer detection methods have significantly improved cancer survival rates. There is increasing evidence to...
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