In a nutshell This study aimed to investigate the combination of letrozole and taselisib as a neoadjuvant treatment (before surgery) in patients with hormone receptor-positive, HER2-negative, early stage breast cancer. This study concluded that this treatment...
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Talazoparib before surgery for patients with BRCA mutated breast cancer
In a nutshell This study aimed to investigate the effectiveness and safety of talazoparib as a neoadjuvant agent (treatment before surgery) in patients with BRCA mutation and operable breast cancer. This study concluded that this treatment was a safe and effective in these patients. Some...
Read MoreSearching for patients with early stage breast cancer to trial a new radiation treatment plan
In a nutshell The trial aims to investigate a new way of delivering radiation therapy in women with early-stage breast cancer. This will involve low doses of radiation therapy being aimed at the part of the breast where the tumor is or was. The main outcomes that will be measured are side effects and recurrence rate. This trial is recruiting in Missouri,...
Read MoreComparing two types of surgery for low rectal cancers
In a nutshell This study aimed to investigate two techniques used to treat low rectal cancer, abdominoperineal resection (APR) and intersphincteric resection (ISR). This study found there was no significant difference in long-term outcomes for APR and ISR. Some background APR is a common surgery to remove low rectal cancers. A low rectal...
Read MoreLength of treatment with trastuzumab in HER2+ early stage breast cancer
In a nutshell This study wanted to find out what the best length of treatment with trastuzumab (Herceptin) is for HER2+ early stage breast cancer. The study found that at least one year of treatment had the best results in terms of how well it worked, and the cost-effectiveness. Some background HER-2 positive breast cancer is a type of cancer where...
Read MoreSurgical treatment options for anal melanoma
In a nutshell This study compared the afety and effectiveness of two surgical treatments for anal melanoma. The study found that patients who had a local excision and patients who had an abdominoperineal resection had the same level of overall survival. Some background Anal melanoma is a very rare cancer. Two surgical options for treatment are...
Read MoreImpact of surgery for early-stage invasive breast cancer
In a nutshell This study aimed to evaluate patients treated for early stage breast cancer in terms of overall survival and recurrence risks. Among patients with early-stage breast cancer; clinical outcomes more than 10 years after diagnosis did not differ between breast-conserving therapy plus radiation or mastectomy plus radiation...
Read MoreSearching for stage I-III breast cancer patients to test omega-3 supplementation
In a nutshell This trial aims to evaluate the use of omega-3 fatty acid supplements to prevent side effects caused by aromatase inhibitors. Aromatase inhibitors can cause arthralgia (bone and joint pain). The main outcomes to be investigated are the change in pain score and the change in joint symptoms. This trial is taking place in Cleveland and...
Read MoreSearching for younger breast cancer survivors to test behavioral techniques for improved quality of life
In a nutshell This phase 3 trial aims to evaluate the effectiveness of mindfulness meditation or survivorship education in improving behavioral symptoms in younger stage 0-III breast cancer survivors. The main outcome to be investigated is the change in depressive symptoms. This trial is taking place in the states of California, Maryland and...
Read MoreComparing neoadjuvant options for HER2+ breast cancer
In a nutshell This study aimed to compare the pathological complete response (pCR) rates of two neoadjuvant therapy combinations for HER2 positive (HER2+, dependent on HER2 for growth) breast cancer. This study concluded that the combination of pertuzumab (Perjeta), trastuzumab (Herceptin) and chemotherapy resulted in higher pCR rates than...
Read MoreHow soon after surgery should breast cancer patients start on chemotherapy?
In a nutshell This study aimed to investigate the influence of the time of starting adjuvant chemotherapy on survival outcomes in different types of breast cancer. This study concluded that more aggressive breast cancers require early adjuvant chemotherapy. Some background Surgery to remove the tumor is a commonly used treatment method for...
Read MoreLong-term effects of stereotactic ablative radiotherapy for patients with NSCLC
In a nutshell The authors examined the long-term effects of stereotactic ablative radiotherapy (SABR) in treating patients with stage 1 non-small-cell lung cancer (NSCLC). They concluded that SABR is both safe and effective in the long-term. Some background SABR is a type of radiation used to treat inoperable early stage NSCLC. Studies have shown...
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