In a nutshell This review examined the safety and effectiveness of focal therapies for recurrent localized prostate cancer. The authors concluded that there is early evidence to suggest that focal therapies are well-tolerated and effective for recurrent localized prostate cancer. Some background Radiation therapy is a common treatment for...
Read MoreIn a nutshell This phase 3 trial aims to determine the effectiveness of different ways of performing prostate cancer surgery. The main outcomes to be investigated are surgical complications and cancer recurrence. The trial is recruiting in New Jersey and New York (USA). The details Surgery to remove the prostate (also known as radical...
Read MoreIn a nutshell This phase II trial aims to evaluate the effectiveness of a personalized peptide-based vaccine (Multi-Epitope TARP) on preventing progression of localized prostate cancer. The main outcome to be investigated is disease progression based on blood tests. The trial is recruiting in Maryland (USA). The details Immunotherapy has recently...
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In a nutshell This study looked at the risk of developing contralateral breast cancer (CBC) in patients with or without BRCA mutations. The study concluded that age at the time of first cancer diagnosis is a strong risk factor for CBC in patients with BRCA. Some background Contralateral breast cancer (CBC) is the development of a second new breast...
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In a nutshell This study examined the rates of positive surgical margins in both robot-assisted and open prostate removal surgeries. Some background Prostate cancer patients are often treated with radical prostatectomy (surgical removal of the prostate gland). In the standard, open approach an incision is made in the lower abdomen. In the...
Read MoreIn a nutshell The authors aimed to determine how radiotherapy influenced patient quality of life after treatment. Some background Radiotherapy is a common treatment used in prostate cancer. It targets a direct beam of radiation at the cancer site, minimizing damage to adjacent healthy cells. There are numerous types of radiotherapy, including...
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In a nutshell The authors aimed to assess the benefits of prolonged use of hormone therapy to treat breast cancer in women undergoing the menopause transition. Some background Endocrine or hormone therapy is a type of treatment used to fight cancer cells with the presence of hormone receptors (HR+). Hormones natural to our body such as estrogen or...
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In a nutshell The authors aimed to determine the risk factors for patients developing a fever during chemotherapy for breast cancer. Some background Febrile neutropenia is the term that describes the development of a fever in a patient who has neutropenia; low levels of granulocytes (a type of white blood cell). This can often be caused by...
Read MoreIn a nutshell The authors aimed to determine the effect of phosphodiesterase type 5 inhibitors on penile functioning following prostate surgery. Some background Prostate surgery is a form of treatment that involves surgically removing the prostate gland which can cause erectile dysfunction in some patients. Phosphodiesterase type 5...
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In a nutshell This article looked at the influence of calpain-9 on breast cancer survival following endocrine therapy. Some background Calpain-9 is a protein that is important in the processes of cell signalling (communication between cells). Irregular expression of these proteins can be seen in breast cancer and some of these proteins can even...
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In a nutshell The authors aimed to determine whether age had an effect on patient quality of life after localized prostate cancer treatment. Some background Localized prostate cancer is cancer that is confined within the prostate gland. Treatment for localized prostate cancer can cause undesirable effects in patients, affecting their quality...
Read MoreIn a nutshell The authors aimed to determine the effect of interleukin-2 in treating in-transit skin cancer. Some background In-transit skin cancer is cancer that has progressed into the lymph nodes (sites that hold the immune cells) from the primary site of cancer. Interleukin-2 (IL-2, Proleukin, Aldesleukin) is a man-made protein...
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