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Confined or spread disease-Spread into regional lymph nodes Posts on Medivizor

A longer interval between chemoradiotherapy and surgery improves rectal cancer outcomes

Posted by on Dec 23, 2019 in Colorectal cancer | 0 comments

In a nutshell This study compared the effects of different time intervals between chemotherapy and radiation therapy (CRT) and rectal cancer surgery. Researchers suggested that increasing this interval from 8 weeks to 12 weeks improved treatment response. Some background Over 70% of patients with rectal cancer have locally advanced disease at...

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Vitamin D is associated with improved survival outcomes of patients with advanced colorectal cancer

Posted by on Nov 29, 2019 in Colorectal cancer | 0 comments

In a nutshell This study investigated the association between vitamin D blood levels and survival outcomes in patients with metastatic colorectal cancer (mCRC). Researchers suggested that higher levels of vitamin D in the blood were associated with better survival. Some background CRC is the third most common cancer in the US. Among CRC patients, only...

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Waiting at least 8 weeks for surgery after chemoradiotherapy increases rectal cancer response

Posted by on Jul 28, 2019 in Colorectal cancer | 0 comments

In a nutshell This study investigated the best interval time between chemoradiation therapy and rectal cancer surgery for the best outcomes in patients with rectal cancer. Researchers suggested that waiting at least 8 weeks until the surgery increases the tumor response to the treatment. Some background The standard treatment for locally advanced...

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Does lymph node yield predict survival in locally advanced rectal cancers?

Posted by on Jul 21, 2019 in Colorectal cancer | 0 comments

In a nutshell This study investigated the impact of lymph node yield (LNY) on the outcomes of patients with locally advanced rectal cancer. Researchers suggested that a LNY of 12 or more predict improved survival in these patients. Some background Colorectal cancer is the third most common cancer worldwide. Some patients present with locally advanced...

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Looking for patients with locally advanced rectal cancer to test a chemotherapy treatment

Posted by on Jun 29, 2019 in Colorectal cancer | 0 comments

In a nutshell This phase 2 trial is examining the effectiveness of FOLFOX chemotherapy to treat patients with rectal cancer, without surgery and radiation. The main outcome to be measured will be the tumor response to the treatment. This study is being conducted in New York, US. The details This year an estimated 44,180 people will be diagnosed with...

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Looking for patients with advanced colorectal cancer to test a new drug

Posted by on Jun 28, 2019 in Colorectal cancer | 0 comments

In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced colorectal cancer and other solid tumors.  The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...

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Searching for patients with colorectal cancer to test this new treatment combination

Posted by on Jun 24, 2019 in Colorectal cancer | 0 comments

In a nutshell This phase 2 trial is examining the effectiveness and safety of navarixin (MK-7123) in combination with pembrolizumab (Keytruda) in patients with colorectal cancer (CRC). The main outcome to be measured will be the objective response rate (ORR; tumor shrinkage or disappearance).  The details A treatment option for patients with...

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Searching for patients with previously treated colorectal cancer to test this new immunotherapy option

Posted by on Jun 14, 2019 in Colorectal cancer | 0 comments

In a nutshell This phase 1b trial is examining the effectiveness and safety of cibisatamab in combination with atezolizumab (Tecentriq) after treatment with obinutuzumab (Gazyva) in patients with previously treated metastatic colorectal carcinoma (mCRC).  The main outcomes to be measured will be side effects and...

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Can positron emission tomography predict the outcomes of patients with high risk rectal cancer?

Posted by on May 30, 2019 in Colorectal cancer | 0 comments

In a nutshell This study investigated the use of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to follow-up during treatment and predict the outcomes of patients with high-risk localized rectal cancer. Researchers suggested that this method can be very useful to assess the tumor before the surgery and predict response to...

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Looking for participants to test a new treatment combination for advanced colorectal cancer

Posted by on Apr 17, 2019 in Colorectal cancer | 0 comments

In a nutshell This trial is examining the effectiveness and safety of treatment with nivolumab (Opdivo) and relatlimab in patients with advanced colorectal cancer. The main outcome to be measured will be tumor response to the treatment. This trial is being conducted in Maryland, US. The details Colorectal cancer is the third most common cancer in the...

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Looking for participants to test the effectiveness and safety of vicriviroc in the treatment of advanced colorectal cancer

Posted by on Mar 12, 2019 in Colorectal cancer | 0 comments

In a nutshell This trial is examining the effectiveness and safety of vicriviroc (VIC) plus pembrolizumab (Keytruda) in the treatment of advanced colorectal cancer. The main outcome to be measured is the tumor response to treatment. This trial is being conducted in the US and Canada.   The details Colorectal cancer is the third most common...

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Looking for patients with metastatic colorectal cancer to test a combined treatment

Posted by on Dec 31, 2018 in Colorectal cancer | 0 comments

In a nutshell This phase 3 trial is examining the effectiveness of a combination treatment with panitumumab (Vectibix), leucovorin and fluorouracil after chemotherapy combined with panitumumab in metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is progression-free survival (PFS; time from treatment to...

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