In a nutshell This study compared the safety and effectiveness of whole-pelvis radiotherapy (WPRT) and prostate-only radiotherapy (PORT) in patients with node-positive prostate cancer (PC) (PC that has spread to nearby lymph nodes). The study found that WPRT improves survival without relapse in these patients, with more short-term...
Read More
In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including prostate cancer. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated. These...
Read More
In a nutshell The study compared outcomes of apalutamide (A; Erleada), darolutamide (D; Nubeqa), and enzalutamide (E; Xtandi) in treating nonmetastatic castration-resistant prostate cancer (nmCRPC). The authors found that A and E had better metastasis-free survival (MFS) compared to D. Some background Men with CRPC fail to respond to...
Read More
In a nutshell The aim of this study was to evaluate the safety and effectiveness of combining androgen deprivation therapy (ADT) with docetaxel (Taxotere) plus prednisone (Deltasone) in the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The study found that this combination improved the outcomes of these...
Read More
In a nutshell This study assessed whether olaparib (Lynparza) affected progression-free survival (PFS; survival without cancer worsening) in patients with metastatic castration-resistant prostate cancer (mCRPC) and certain genetic mutations (abnormalities). The study found that olaparib improved PFS in these patients. Some...
Read More
In a nutshell This study compared 6-month and 18-month courses of hormonal anti-androgen treatment and radiotherapy (RT) in patients with locally advanced prostate cancer (LAPC). The results showed that 18-month treatment was most effective, especially when used with high dose brachytherapy RT. Some background Androgens (such as testosterone) are...
Read MoreIn a nutshell This trial is looking at using proton-based radiation therapy to target high-risk prostate tumors. The main outcome to be measured is the rate of recurrence 5 years after the end of the treatment. This study is taking place in Florida, USA. The details Prostate cancer can be treated by medication, surgery or radiation....
Read More
In a nutshell This study examined the benefit of radiation to limited sites of cancer spread (metastases) in men no longer responding to hormone therapy. Researchers reported effective local cancer control after radiation of lymph node metastases in patients no longer responding to hormone therapy. Some background Hormone therapy is the...
Read More
In a nutshell This study examined prostate surgery as a treatment option for prostate cancer with lymph node involvement. Researchers reported that prostate surgery alone is associated with good treatment outcomes in men with low levels of prostate cancer spread. Some background In some patients, prostate cancer cells can spread to local lymph...
Read More
In a nutshell This study examined the benefits of prostate surgery among older men with high-risk prostate cancer and additional medical conditions. Researchers concluded that prostate surgery is a suitable treatment option for older high-risk prostate cancer patients with few additional medical conditions. Some background Surgical removal of the...
Read More
In a nutshell This study examined the potential benefit of early intensive hormonal therapy (combined androgen blockade) in men with high-risk local prostate cancer, given before surgery. Researchers concluded that intensive hormone therapy may be more effective than standard treatment in reducing androgen levels, but seldom results in complete tumor...
Read MoreIn a nutshell The authors analysed the effect of positive surgical margins on cancer-specific survival. Some background When tumors are removed, typically extra tissue around the tumor is also removed to increase the likelihood of removing all the cancer cells. Estimating surgical margins involves examining this extra tissue after or during...
Read More
