In a nutshell This study investigated whether a single blood pressure (BP) pill containing 4 drugs (quadpill) at quarter doses is more effective than the standard dose of a single drug as initial treatment in patients with hypertension. The data showed that a quadpill was safe and more effective in getting BP under control than the standard...
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In a nutshell This study looked at patients on triple therapy for blood pressure control. It found that taking fewer separate pills was associated with better blood pressure control. Some background Blood pressure (BP) can be difficult to manage in some patients. There are three main types of treatment that act on the body in...
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In a nutshell This study looked at how effectively spironolactone (Aldactone) lowers blood pressure (BP) in patients with resistant hypertension (RH). They found that spironolactone significantly lowers BP in some patients after three months. Some background High BP can lead to strokes and heart attacks. There are many types of...
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In a nutshell This study evaluated the effectiveness of a triple combination drug treatment of high blood pressure (BP) in one fixed-dose tablet. The authors concluded that one tablet containing a low-dose of 3 BP-lowering medications was more effective than usual care in controlling BP. Some background High blood pressure (BP) remains...
Read MoreIn a nutshell This phase 2 trial will investigate the safety and effectiveness of KBP-5074 for the treatment of hypertension. The main outcome will be a change in blood pressure after 84 days. The details Hypertension or high blood pressure is a serious condition. It can lead to major cardiac events such as stroke, heart attack or death....
Read MoreIn a nutshell This study investigated a fixed-dose combination of amlodipine and valsartan (AML/VAL) for the treatment of hypertension. They found that AML/VAL reduced blood pressure in patients with poor response to VAL alone. Some background Hypertension or high blood pressure (BP) is a common condition. Managing BP levels in patients with...
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In a nutshell This study investigated if a low-dose, triple-combination pill (LD-TCP) could reduce blood pressure (BP) in patients with persistent hypertension (PHT). They found that LD-TCP increased the chance of reaching BP target after 6 months. Some background Hypertension or high blood pressure is a common condition. Managing blood pressure...
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In a nutshell This study investigated if aquatic exercise had an effect on blood pressure levels in older women with hypertension (high blood pressure). The study determined that aquatic exercise caused a greater reduction in blood pressure compared to land-based exercise in the short-term. Some background Hypertension is a serious...
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In a nutshell This study examined the safety and effectiveness of a lercanidipine (Zanidip)/enalapril (Vasotec) combination in patients with hypertension. The authors concluded that a combination of these drugs given at 20mg each per day is the most effective dosage and is well tolerated. Some background Patients with hypertension have a higher...
Read MoreIn a nutshell This study compared the effect of thiazide-type (TT) and thiazide-like (TL) diuretics on heart failure, cardiovascular events (CVEs, such as heart attacks and strokes) and mortality in adults with hypertension. The authors concluded that patients receiving TL diuretics were less likely to experience cardiovascular events and heart failure...
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In a nutshell This paper compared the effect of renal denervation to medication alone in patients with resistant high blood pressure. The authors concluded that renal denervation and intensified medical treatment is similar have similar effects on blood pressure. Some background Resistant hypertension is high blood pressure which cannot be...
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In a nutshell This paper compared the effect of zofenopril or irbesartan (Avapro) plus a thiazide diuretic on blood pressure in arteries of elderly patients. A combination of a thiazide diuretic plus zofenopril or irbesartan was found to be effective in lowering blood pressure. Some background Systolic blood pressure is the blood pressure...
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