In a nutshell This study looked at how beta-blockers affected patients following a heart attack. It found that patients using a low dose of beta-blockers had better outcomes one year later. Some background Following a heart attack, there are several treatment options available to improve outcomes. One treatment is beta-blockers (BBs), which prevent...
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In a nutshell This study compared the use of two beta-blockers, carvedilol (Coreg) and metoprolol (Lopressor), after a heart attack. It found that they had similar results on most patient groups. However, carvedilol improved survival in patients with reduced heart function. Some background Beta-blockers are a group of medications that...
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In a nutshell This study investigated if certain types of anti-hypertensive drugs (AHTs) reduce risks after revascularization procedures for a heart attack. They found that beta-blockers (BBs) and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) reduce cardiovascular events (CVEs) after revascularization. Some...
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In a nutshell This study compared ticagrelor (Brilique) and prasugrel (Efient) as a maintenance antiplatelet therapy (APT) after a myocardial infarction (MI; heart attack). They found that ticagrelor had a better APT effect and fewer bleeding events. Some background Coronary artery disease (CAD) is a condition that leads to...
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In a nutshell This study investigated the effects of different drug-eluting stents (DES) in percutaneous coronary intervention (PCI) in patients who have had a heart attack. They found that biodegradable sirolimus (BS) stents were better than durable polymer everolimus (DPE) stents in improving blood flow. Some background Percutaneous...
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In a nutshell The aim of this study was to compare the effectiveness of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) in protecting the heart in patients with diabetes that have had a heart attack and who had stents placed. The main finding of the study was that ACEI reduced the risk of major adverse...
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In a nutshell This study investigated if clopidogrel (Plavix) and aspirin are effective when taken together for treating coronary artery disease (CAD). They found that clopidogrel and aspirin improved CAD symptoms compared to aspirin alone. Some background Coronary artery disease (CAD) is caused by reduced blood flow to the heart. This leads...
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In a nutshell This study aimed to investigate the long-term effects of different treatments for patients with myocardial infarction with non-obstructive coronary artery (MINOCA) disease. This study concluded that statins and ACE inhibitors/angiotensin receptor blockers provided long-term benefit to patients with MINOCA disease. Some background...
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In a nutshell This study aimed to investigate if using both an angiotensin converting enzyme (ACE) inhibitor and a dipeptidyl peptidase 4 inhibitor, alogliptin (Nesina) in type 2 diabetes mellitus patients with recent acute coronary syndrome led to increased risk of cardiovascular events. This study concluded there was no increased risk of...
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In a nutshell This study aimed to determine the timing of mortality and other non-fatal adverse events according to diabetic status and type of acute coronary syndrome (ACS). It was found that the type of ACS but not the diabetic status determines the timing of fatal and non-fatal adverse events. Some background Patients with diabetes mellitus...
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In a nutshell This paper studied the long-term risk of stroke in patients who have survived a heart attack. Patients were at increased risk of a stroke up to 30 years after a heart attack. Some background After a heart attack, about 2 to 4 in 100 patients have a stroke (not enough blood supply reaching the brain). A stroke can be ischemic...
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In a nutshell This paper looked at effect of statin treatment after heart attack in elderly patients. Patients who started statin treatment did not have differences in cognition and physical abilities compared to patients who did not start statin treatment. Some background Statins are a group of drugs that work to reduce levels of...
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