In a nutshell This study evaluated the long-term impact of 10-kHz spinal cord stimulation (SCS) in patients with painful diabetic neuropathy (PDN; nerve disease) and refractory symptoms. The data supported the use of 10-kHz SCS for important, durable pain relief over 12 months in these patients. Some background Diabetic sensorimotor peripheral...
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In a nutshell This study compared the effectiveness of chiglitazar (Bilessglu) and sitagliptin (Januvia) on glycemic (blood glucose) variations, insulin resistance, and inflammation levels in patients with type 2 diabetes (T2D). The data showed that chiglitazar treatment was more effective at improving insulin resistance and inflammation compared...
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In a nutshell This study evaluated the effect of physical activity interventions on glycemic variability (GV; glucose levels variations) in patients with diabetes. The data showed that physical activity was associated with significantly reduced GV in these patients. Some background Physical activity has been shown to reduce hemoglobin A1c (the...
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In a nutshell This study reviewed the long-term use of sodium-glucose co-transporter 2 inhibitors (SGLT-2i) on the risk of mortality and hospitalization for heart failure (HHF) in patients with type 2 diabetes (T2D) and heart failure (HF). The authors concluded that long-term use of SGLT-2 inhibitors can help to reduce mortality risk and HHF in...
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In a nutshell This review assessed the risk of hypoglycemia (dangerously low blood glucose) with the addition of sodium-glucose co-transporter 2 (SGLT-2) inhibitors to sulfonylureas in patients with type 2 diabetes (T2D). The authors concluded that this combination was associated with an increased risk of hypoglycemia. Some background...
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In a nutshell This study evaluated the safety of anti-diabetic drugs in the risk of fractures based on available data from clinical trials. The data showed differences in associations between the use of anti-diabetic drugs and fracture risk. Some background Patients with type 2 diabetes (T2D) are more prone to bone fragility (increased bone...
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In a nutshell This study evaluated the effectiveness of insulin glargine 100U/ml (iGlar; Lantus) and lixisenatide (Lixi; Lyxumia) combined (iGlarLixi; Soliqua) compared with each of the two drugs alone in patients with type 2 diabetes (T2D) that was uncontrolled with 2 anti-diabetic oral drugs. The data showed that iGlarLixi...
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In a nutshell This study compared the effectiveness and safety of tirzepatide to insulin degludec (Tresiba) in patients with uncontrolled type 2 diabetes (T2D). The data showed that tirzepatide produced better blood glucose control and body weight improvements with reduced risk of hypoglycemia, compared to degludec in these patients. Some...
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In a nutshell This study investigated the change in central retinal thickness (CRT) by optical coherence tomography (OCT) in patients with type 2 diabetes (T2D) after 12 weeks of treatment with dapagliflozin (Farxiga) or glibenclamide (Diabeta). The authors concluded that CRT may improve with short-term use of dapagliflozin compared with...
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In a nutshell This study investigated the effect of exenatide (EXE; Byetta) on kidney function, obesity and glucose control in overweight or obese patients with type 2 diabetes (T2D). The data showed that EXE could assist in improving kidney function, glucose control, and inflammation after 24 weeks of treatment. Some background Diabetic...
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In a nutshell This study assessed the effectiveness and safety of different long-acting and short-acting insulins for the treatment of patients with diabetes. The data supported the use of long-acting insulins instead of neutral protamine Hagedorn (NPH) insulin (Humulin N; Novolin N), as basal insulin for patients with type 2 diabetes (T2D). Some...
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In a nutshell This study compared canagliflozin (Invokana) to teneligliptin (Teneria) for patients with type 2 diabetes (T2D). It found that canagliflozin led to greater improvement in body weight and metabolic outcomes in these patients. Some background T2D is a health condition of the metabolism. T2D prevents the body from responding well to the...
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