In a nutshell This study looked at the use of metformin (Glucophage) for the management of type 2 diabetes (T2D) in pregnancy. The study showed that compared to infants exposed to placebo, those exposed to metformin during pregnancy did not show any signs of increased weight or body mass index (BMI; a measurement of weight in relation to...
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In a nutshell This review assessed the effectiveness and safety of ultra-rapid insulin analogs (URIAs) with continuous subcutaneous insulin systems (CSII) in adults with type 1 diabetes (T1D). The authors concluded that URIAs were compatible with CSII systems and had a better glucose-lowering effect after meals compared to rapid-acting insulin...
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In a nutshell This study analyzed the long-term effect of behavioral counseling on increasing daily physical activity (PA) and reducing sedentary (SED) time on changes in beta-cell (β-cell) function and glucose control in patients with type 2 diabetes (T2D). The authors concluded that increasing moderate-to-vigorous-intensity physical activity...
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In a nutshell This study compared intermittent scanning continuous glucose monitoring (isCGM) with real-time continuous glucose monitoring (rtCGM) for the treatment of type 1 diabetes (T1D). It found that compared to isCGM, rt CGM resulted in increased time spent in range and improved blood glucose control in these patients. Some background...
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In a nutshell This study evaluated the effectiveness and safety of combinations of anti-depressive medication for the treatment of diabetic peripheral neuropathic pain (DPNP) in patients with diabetes. The study showed that combination treatment improved pain in these patients and was well tolerated. Some background DPNP occurs in patients...
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In a nutshell This study compared the effect of very low carbohydrate (VLC) or ketogenic diets (KDs) with higher carbohydrate diets in patients with pre-diabetes or type 2 diabetes (T2D). The data showed that reduced levels of glycated hemoglobin (HbA1c) and triglycerides may occur with VLC or KDs, but with limited advantages over other diets. Some...
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In a nutshell This study assessed the effect of subcutaneous semaglutide (Ozempic) on body composition in patients with type 2 diabetes (T2D). The data showed significant weight loss in these patients after 3 months of semaglutide treatment based on reduced visceral adipose tissue (VAT) thickness and fat mass (FM). Some background T2D is...
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In a nutshell This analysis investigated the relationship between anti-diabetic medications and the risk of fractures in patients with type 2 diabetes (T2D). The data showed that glucagon-like peptide-1 receptor agonists (GLP1-RAs) and sulfonylurea (SU) provided better protection against fractures compared to thiazolidinedione (TZD) or dipeptidyl...
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In a nutshell This study reviewed the effect of high-dose vitamin D2 (ergocalciferol) supplementation on delaying the onset of type 1 diabetes (T1D) in children and adolescents with newly diagnosed T1D. The authors recommended maintaining a safe and effective high-dose vitamin D2 concentration of 30-60 ng/mL for delaying the onset of T1D in...
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In a nutshell This study evaluated the effects of the plant-based polyphenol-rich extract TOTUM-63 on glucose control in patients with prediabetes or early-stage newly diagnosed type 2 diabetes (T2D). The data showed that TOTUM-63 was safe and lowered fasting blood glucose in these patients. Some background Patients with...
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In a nutshell This study evaluated the most effective and safe dose of dapagliflozin (Farxiga) as an additional treatment to insulin in patients with type 1 diabetes (T1D). The authors concluded that 10 mg of dapagliflozin as an add-on to insulin treatment resulted in improved blood glucose (sugar) control, reduced insulin dosage, and body...
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In a nutshell This review analyzed the effectiveness and safety of nutrient supplements for the control of blood glucose and insulin resistance in patients with type 2 diabetes (T2D). The authors concluded that there is currently a lack of sufficient clinical evidence to support the use of nutrient supplements for blood glucose control and improved...
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