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Posted by on Sep 16, 2019 in Prostate cancer | 0 comments

In a nutshell

This study aimed to investigate a new way to evaluate prostate cancer risk, through the total testosterone density (TTD). This study found that TTD can be used to help manage patients with low-risk PCa.  

Some background

Testosterone is a hormone that is made by the testicles. It usually fuels the growth of prostate cancer (PCa) tumors. This can be measured in the blood as a tumor marker. After surgery, if any cancer cells remain, the size of the remaining tumor is called a tumor load. The ratio between the testosterone levels and tumor load is called the total testosterone density (TTD). It is unknown if the TTD has a bearing on patients with low risk PCa. 

Methods & findings

This study included 144 patients with low-risk PCa. 104 patients had unfavorable risk factors. For example, a tumor being upgraded to a higher risk after surgery. Tumor load of more than 20% was also considered an unfavorable risk factor. 

TTD was associated with a higher body weight, a higher prostate volume, and prostate-specific antigen (PSA; a blood marker of PCa). In low-risk PCa patients, TTD was associated with a high tumor load. 

The bottom line

This study found that TTD is associated with tumor load and can be used to help better manage patients with low risk PCa.  

The fine print

This study was based on medical records. Testosterone levels were only measured once. This might not represent the real status of a patient treated for PCa. Further studies are needed for stronger evidence.

Published By :

International urology and nephrology

Date :

Aug 23, 2019

Original Title :

Total testosterone density predicts high tumor load and disease reclassification of prostate cancer: results in 144 low-risk patients who underwent radical prostatectomy.

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