In a nutshell
This study investigated the effectiveness of repeat sessions of intermittent theta burst stimulation (ITBS) treatment in patients with Parkinson's disease with decreased reasoning functioning. Researchers suggested that ITBS might improve overall mental performance in these patients.
Some background
Parkinson's disease (PD) affects brain cells. The abilities controlled by these cells are lost causing symptoms such as muscle weakness and tremors. These patients can also have mental symptoms such as slow thinking and processing, difficulty in making decisions or even communicating. Very few therapies are available to treat mental symptoms or stop their progress.
ITBS is a non-invasive method that stimulates brain cells through electromagnetic pulses. Prior studies showed that ITBS improves mental symptoms of healthy individuals with depression. However, the effectiveness of ITBS in patients with PD and mental symptoms is not clear.
Methods & findings
This study included information about 28 patients with PD and mental symptoms. They received ITBS treatment (14) or placebo (14). The treatment was received twice a day for 3 days with 1 to 2 days in between. Follow-up was performed before ITBS and on days 1, 10 and 30 after the last ITBS session.
The ITBS group showed an improvement in overall mental symptoms. Improvements were seen regarding attention for both groups. However, only the ITBS group had an improved visuospatial function (mental process necessary to recognize space and forms).
The bottom line
This study concluded that ITBS improves mental symptoms in patients with PD.
The fine print
This study had a very small number of patients and a short follow-up period. Larger and longer-term studies are needed.
Published By :
Parkinsonism & related disorders
Date :
Jul 08, 2019
