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Posted by on Jan 20, 2019 in Overactive bladder | 0 comments

In a nutshell

This study aimed to investigate the effectiveness of onabotulinumtoxinA (Botox) compared to mirabegron (Myrbetriq) used to treat patients with overactive bladder (OAB). This study found that Botox might be more effects in the treatment of OAB.

Some background

Overactive bladder (OAB) occurs when the bladder muscle is too active. Instead of staying at rest as urine fills the bladder, the bladder contracts. This causes a person to feel a sudden and sometimes overwhelming urge to urinate even when the bladder is not full. Treatments for OAB can include Botox and mirabegron

It is unclear which treatment is more effective for the treatment of OAB. 

Methods & findings

This study reviewed 19 other studies. Patients in these studies were given Botox or mirabegron compared to placebo. 

Both medications were more effective in treating OAB symptoms than placebo. These symptoms included urinary frequency, urgency when urinating and urinating at night.

Botox was more effective compared to mirabegron in reducing daily urinary leakage and frequency. Some patients found that urinary incontinence completely stopped with Botox treatment.

The bottom line

This study found that Botox is more effective than mirabegron for the treatment of OAB.

The fine print

Patients using Botox had more loss of urinary control and urgency at the beginning of the study than patients taking mirabegron.

Published By :

BMJ Open

Date :

Feb 23, 2016

Original Title :
Comparative assessment of onabotulinumtoxinA and mirabegron for overactive bladder: an indirect treatment comparison.
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