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Posted by on Apr 9, 2018 in Leukemia | 0 comments

In a nutshell

This study aimed to compare pediatric-inspired intensive therapy and non-intensive therapy for older patients with acute lymphoblastic leukemia.

This study concluded that pediatric-inspired intensive therapy improves the outcome for these patients when compared to the non-intensive therapy.

Some background

Acute lymphoblastic leukemia (ALL) in younger adults has recently been treated with pediatric inspired intensive therapy regimens. These intensive regimens include the use of continuous high-dose chemotherapy and high doses of non-myelotoxic drugs (not suppressing bone marrow).  This pediatric inspired regimen has been tested in adults ranging from 30 to 55 years of age. However there has been little testing in adults aged older than 55 years and is a lack of information on the outcomes for these patients.  

It was not known if the intensive or non-intensive therapy would be more effective for older patients with ALL.

Methods & findings

This study involved patients aged 55 to 65 years who had Ph-negative ALL. 67 patients received pediatric-inspired intensive treatment (PI group) and 44 patients received semi-intensive treatment (SI group). The treatments were compared. The PI group was followed for an average of 49 months. The SI group was followed for an average of 21 months.

The PI group had a complete remission (no cancer left) rate of 85% compared to 64% in the SI group. The PI group had a 39% cumulative incidence of relapse (cancer returns) compared to 60% in the SI group. The PI group had a 28% cumulative incidence of treatment-related mortality compared to 21% in the SI group. The PI group had a rate of 37% for event free survival (time from treatment until relapse or death) at 2 years compared to 21% in the SI group.

The bottom line

This study concluded that PI treatment improves the outcome for older adults with ALL when compared to SI treatment.

What’s next?

Consult your physician about both SI and PI treatment options.

Published By :

Leukemia Research

Date :

Mar 19, 2018

Original Title :

Comparison of intensive, pediatric-inspired therapy with non-intensive therapy in older adults aged 55-65 years with Philadelphia chromosome-negative acute lymphoblastic leukemia.

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