In a nutshell
This study investigated if hepatitis B virus (HBV) infection is associated with pregnancy outcomes in infertile women undergoing in vitro fertilization (IVF). They found that HBV infection did not affect pregnancy outcomes.
Infertility is a growing problem worldwide. The cause of infertility is not always clear. Certain factors may affect fertility. Hepatitis B virus infection is a common health issue. HBV infection can lead to a number of serious conditions. It can cause inflammation in the liver (hepatitis) and scarring (cirrhosis). It can also lead to liver cancer. HBV infection rates are high worldwide. Many people do not display symptoms (healthy carriers).
Some studies suggest that HBV infection may affect fertility and pregnancy outcomes. Reduced pregnancy rates (PRs) and implantation rates have been linked to HBV infection. Other studies show no association between HBV infection and pregnancy outcomes. It is unclear if HBV infection affects pregnancy outcomes in women undergoing in vitro fertilization (IVF).
Methods & findings
This study included 8,550 women with HBV undergoing IVF. They were compared to 7,656 women without HBV infection who were also undergoing IVF. Pregnancy outcomes were analyzed in HBV-positive (HBV-P) and negative (HBV-N) patients. These included miscarriage, pre-term delivery and live birth rates (LBR). Pregnancy complications were also analyzed.
Implantation rate was significantly lower in HBV-P women. However, all other pregnancy outcomes were similar in both HBV-P and HBV-N women. HBV-P women had higher rates of ovulatory disorders. Fertility hormone levels were also lower in HBV-P women.
The bottom line
The authors concluded that HBV infection did not affect pregnancy outcomes in infertile women undergoing IVF.
The fine print
This study was conducted in China. The findings may not extend to other regions. IVF protocols varied and some patient data may not have been available. More investigation is needed.
If you have any concerns regarding fertility, please consult with your doctor.
Published By :
Fertility and Sterility
May 15, 2019