Growth hormone and IVF: are there added benefits for older women?

This study investigated the effects of growth hormone (GH) during in vitro fertilization (IVF).

They found that GH treatment improved fertility in older women.

Fertility naturally declines with age. The number and quality of oocytes (eggs) lowers over time. Hormonal changes make it more difficult to become pregnant. Some women may opt for in vitro fertilization (IVF). The first step of IVF involves harvesting oocytes from the ovaries. To do this, patients are usually prescribed follicle-stimulating hormone (FSH). Some women do not respond well to FSH. Growth hormone (GH) may be a useful alternative.

GH is involved in a number of body functions. GH receptors are located on follicle cells. The follicle contains the oocyte. It also contains cells and proteins. These cells and proteins support the oocyte. They are involved in the maturation of the oocyte. GH treatment may improve oocyte maturation. GH treatment has also been associated with a reduced chance of miscarriage. It is unclear exactly what effects GH has on IVF outcomes. 

This study included 62 patients undergoing IVF. Patients underwent a standard protocol for harvesting oocytes. Women that were unresponsive to standard therapy were also treated with GH. The hormonal profile of patients, pregnancy rates and live birth rates were analyzed.

GH treatment led to an increase in the levels of GH receptors (GHRs) on support cells. This was found in women between the age of 31 and 45. This was associated with an improved fertility profile in older patients. GH treatment signficantly improved pregnancy rates. The live birth rate was also higher in GH-treated patients. 

The authors concluded that GH treatment improved fertility outcomes in older patients undergoing IVF.

This study was observational. More investigation is needed on the mechanism of GH in fertility outcomes. 

If you have any concerns regarding infertility treatment, please consult with your physician.