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Posted by on Apr 28, 2019 in Hodgkin's lymphoma | 0 comments

In a nutshell

This study aimed to investigate the frequency of advanced colorectal neoplasia (ACN; abnormal growth of tissue in the bowel) in Hodgkin lymphoma (HL) survivors. 

This study concluded that HL survivors treated with abdominal radiotherapy and/or alkylating chemotherapy have a high frequency of ACN.  

Some background

Advanced colorectal neoplasia (ACN) is a type of abnormal and excessive growth of tissue in the area of the colon and rectum. ACN includes advanced adenomas, advanced serrated lesions (a precancerous growth) and colorectal cancer (CRC). The risk of ACN is increased in survivors of Hodgkin lymphoma (HL) who have been treated with abdominal radiotherapy and/or alkylating chemotherapy such as procarbazine (Matulane). However, the actual frequency of ACN in HL survivors is still unknown. 

Methods & findings

This study involved 101 HL survivors treated with abdominal radiotherapy and/or procarbazine. All participants underwent a colonoscopy.  The frequency of ACN was measured. The results were compared with those for 1426 Dutch people without HL that underwent a screening colonoscopy (the control group). 

25% of the HL survivors experienced ACN compared to 12% in the Dutch general population. 14% of the HL survivors experienced advanced adenomas compared to 9% in the control group. 12% of the HL survivors experienced advanced serrated lesions compared to 4% in the control group. 

The bottom line

This study concluded that HL survivors treated with abdominal radiotherapy and/or procarbazine have a high frequency of ACN. They suggested that a colonoscopy surveillance program should be considered in these patients. 

The fine print

This study used a Dutch population for comparisons. Different populations have different colorectal cancer risks. Further studies are needed in more diverse populations.

What’s next?

If you have concerns about the risk of ACN, please consult with your physician.

Published By :

Cancer

Date :

Dec 18, 2018

Original Title :

High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors.

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