Comparing surgery, collagenase clostridium histolyticum, and penile traction therapy in men with Peyronie’s disease

This study aimed to compare treatments for Peyronie's disease (PD). This study found that traction devices represent the most cost-effective treatment for PD. 

Peyronie's disease (PD) is caused by scar tissue that forms inside the penis. It can result in a bent, rather than straight, erect penis. It reduces the quality of life of patients. A traction device called Restore X (RX) can be used. Collagenase Clostridium histolyticum (CCH) injections are another option. Surgery to remove scar tissue is another option. 

It is unclear which option is best in terms of cost and effectiveness in these patients. 

This study included 201 men with PD. 63 men were treated with the RX. There were 115 men treated with CCH and 23 with surgery (plication or incision and grafting).

Overall, surgery was 96% effective. CCH was 66% effective. RXPTT was 48% effective. At 10 years after treatment, RX was the most cost-effective with an average cost of $883 per patients. CCH and surgery both resulted in a quality of life similar to RX, but with significantly higher costs ($11419 – surgery and $33628 – CCH).

This study found that RX was the most cost-effective treatment for PD. The authors suggested that depending on the outcomes the patients desire, surgery, and CCH are also effective treatment options.

This study compared only 3 treatment options for PD. Other therapies exist for this condition. More research is needed.

Consult your urologist to see which is the appropriate treatment in your situation.