In a nutshell
This study investigated if vitamin D supplementation improves colorectal cancer (CRC) survival outcomes. Researchers suggested that vitamin D supplementation is associated with improved survival in CRC.
Some background
CRC is the third most common cancer diagnosed in both men and women in the US. It is more common in developed countries indicating that there is an external (environmental) factor important for the disease.
Vitamin D is a nutrient that the body needs to function and stay healthy. It helps the body to use calcium to make strong bones and is also involved in the immune response. This vitamin can be found in eggs, fish, and dairy products. Once this vitamin is in the body, it needs the sunlight to get activated and perform its function.
A low vitamin D level has been associated with several common cancers. A low level of vitamin D has also been associated with a poorer survival in patients with CRC. However, the effects of vitamin D supplementation in patients with CRC are not clear.
Methods & findings
This study analyzed the results of 7 other studies evaluating the effects of vitamin D supplementation in patients with CRC. Overall, 957 patients with CRC were included.
An analysis in 5 trials with 815 patients showed a 30% improvement in the odds of better cancer outcomes with vitamin D supplementation. Patients who received vitamin D supplements had a 33-35% improvement in the odds of a better survival without cancer worsening. These patients also had a 24% improvement in the odds of better cancer-specific survival.
The bottom line
This study concluded that vitamin D supplementation is associated with a positive effect on the survival of patients with colorectal cancer.
The fine print
This study did not consider different genetic factors related to the metabolism of vitamin D. These factors are specific to each patient. Also, all studies had different protocols and included different vitamin D doses. More studies are needed.
What’s next?
Discuss with your doctor the benefits of vitamin D supplementation.
Published By :
British Journal of Cancer
Date :
Sep 15, 2020
