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Posted by on Oct 20, 2019 in Colorectal cancer | 0 comments

In a nutshell

This study investigated the effectiveness of physical activity (PA) on the outcomes of patients with advanced colorectal cancer. Researchers suggested that regular PA is associated with better outcomes for these patients.

Some background

Colorectal cancer is the third most common cancer worldwide. A significant number of patients present advanced disease at diagnosis. A lifestyle with little or no physical activity is associated with increased recurrence and mortality risk. The effect of PA on advanced colorectal cancer remains poorly studied. Prior studies suggested that PA is associated with colorectal cancer survival. However, these studies were limited, with small populations.

Methods & findings

The objective of this study was to investigate the effects of PA in advanced colorectal cancer. This study included 1218 patients with metastatic (spread to other parts of the body) colorectal cancer. One month after therapy, patients completed a questionnaire reporting PA over the previous 2 months. Overall survival (OS; time from treatment to death by any cause) was the main outcome to be measured. Followed by progression-free survival (PFS; time from treatment to disease progression) and toxicity of treatments.

Patients who reported 18 hours per week or more of PA had a 15% improvement in the odds of a better OS compared to those who had less than 3 hours per week of PA. The same patients had a 17% improvement in the odds of a better PFS. Patients who exercised for 9 or more hours a week had a 27% improvement in the odds of having fewer side effects to treatments.

The bottom line

The authors concluded that regular PA improves the PFS and side effects to treatments of patients with advanced colorectal cancer.

The fine print

This study is based on self-reported patient questionnaires. Data collected in this way is not always reliable. More studies are needed for stronger evidence.

Published By :

Journal of clinical oncology

Date :

Aug 13, 2019

Original Title :

Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405.

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