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Posted by on Nov 13, 2017 in Benign prostatic hyperplasia | 0 comments

In a nutshell

This study looked at the effect of adding dutasteride (Avodart) to patients already on ineffective drug treatment for an enlarged prostate and bladder symptoms. The study found that adding dutasteride reduced detrusor (muscle of the bladder) size and bladder problems.

Some background

Patients with enlarged prostates and urinary symptoms are often treated with tamsulosin (Flomax) to reduce prostate size. This treatment is not always effective on its own. It is necessary to assess if adding on dutasteride improves bladder and prostate symptoms. These symptoms include bladder control, prostate size, and blocking urine flow.

Methods & findings

27 men had dutasteride added on to their tamsulosin treatment. Factors such as prostate size and urine flow were measured.

Dutasteride improved bladder symptoms by 46.7% and reduced prostate size by 13%.

After 24-weeks follow-up, the risk of an enlarged prostate blocking urine flow, was reduced.

The bottom line

The study concluded that dutasteride significantly reduced prostate size and bladder problems when added-on to treatment.

The fine print

The study does not mention if dutasteride added-on would work on all therapies. It is necessary to study patients on different treatments.

What’s next?

Talk to your doctor about adding dutasteride to your treatment.

Published By :

Neurourology and urodynamics

Date :

Mar 03, 2017

Original Title :

Dutasteride add-on therapy reduces detrusor mass in patients with benign prostatic enlargement not satisfied with alpha-adrenergic antagonist monotherapy: A single center prospective study.

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