In a nutshell This study investigated the best first-line therapy to add to bevacizumab (Avastin) treatment in patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that irinotecan (Camptosar) plus bevacizumab improved the outcomes of these patients. Some background Colorectal cancer is...
Read MoreType(s) of colorectal cancer (CRC)-Adenocarcinoma of the rectum Posts on Medivizor
Survival of patients with rectal cancer followed-up by the watch and wait method after chemoradiotherapy
In a nutshell This study investigated the outcomes of patients with rectal cancer who were followed up with the watch and wait method after chemoradiotherapy (CRT). Researchers suggested that this strategy can effectively identify patients who can have a less frequent follow-up if they maintain response for the first 3 years...
Read MoreComparing outcomes in robotic and open surgery for patients with rectal cancer
In a nutshell This study compared the effectiveness of open surgery (OS) and robotic surgery (RS) in patients with rectal cancer. Researchers suggested that RS and OS provided similar treatment outcomes in these patients. Some background Colorectal cancer is one of the most common cancer worldwide. Rectal cancer makes up for one-third of these cases....
Read MoreLooking for participants to test a treatment combination for metastatic colorectal cancer
In a nutshell This phase 2 trial is examining the effectiveness of TAS-102 (Lonsurf) plus oxaliplatin (Eloxatin) in the treatment of metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured will be the overall response to the treatment rate. This study is being conducted in New Jersey, US. The details...
Read MoreThe effectiveness and safety of regorafenib in older patients with advanced pretreated colorectal cancer
In a nutshell This study investigated the effectiveness and safety of regorafenib (Stivarga) treatment in older patients with colorectal cancer (CRC). Researchers suggested that this treatment has similar effects in younger and older patients. Some background CRC is the third most common cancer worldwide. More than half are diagnosed in patients older...
Read MoreTAS-102 plus bevacizumab treatment in patients with metastatic treatment-resistant colorectal cancer
In a nutshell This study investigated the safety and effectiveness of TAS-102 (trifluridine-tipiracil) with and without bevacizumab (Avastin) therapy in metastatic colorectal cancer (mCRC). Researchers suggested that this combined therapy might be a good treatment option for patients with advanced CRC. Some background Colorectal cancer is the third...
Read MoreDoes chemotherapy after surgery improve survival in high-risk stage 2 colorectal cancer?
In a nutshell This study investigated the effectiveness of chemotherapy after surgery in stage 2 colorectal cancer (CRC). Researchers suggested that this treatment may result in survival improvement but should be individualized. Some background CRC affects 145,600 adults in the US every year. Treatment for this disease is guided by stage at...
Read MoreLooking for participants with advanced colorectal cancer to test a combination therapy
In a nutshell This phase 1/2 trial is examining the effectiveness of standard therapy alone or combined with new drugs as first line treatment for advanced colorectal cancer. The main outcome to be measured will be safety and tumor response to the treatment. The details Colorectal cancer is one of the most common cancers worldwide. A significant...
Read MoreLooking for participants to test a vaccine for the treatment of advanced colorectal cancer
In a nutshell This phase 1b trial is examining the effectiveness and safety of a vaccine treatment, ATP128, in the treatment of advanced colorectal cancer. The main outcome to be measured is the tumor response to the treatment and treatment toxicity. This trial is being conducted in Arizona and California, US. The details Colorectal cancer is the...
Read MoreLooking for participants with metastatic melanoma to test a new immunotherapy
In a nutshell This phase 1 trial is examining the effectiveness of personalized tumor antigens (PTA) in the treatment of different advanced tumors. The main outcomes to be measured will be side effects and disease control. This study is being conducted in Arizona, California, Louisiana and New Jersey, US. The details While the tumor cells are growing,...
Read MoreLooking for participants with advanced cancer to test a new therapy
In a nutshell This trial is examining the effectiveness and toxicity of COTI-2 treatment in patients with advanced cancer. The main outcomes to be measured will be cancer response to the treatment and number of side effects. This study is being conducted in Texas, US. The details Cancer resistance to therapy affects successful cancer treatment. The...
Read MoreLiver surgery is a safe treatment for patients with BRAF-positive colorectal cancer liver metastasis
In a nutshell This study investigated the outcomes of patients with BRAF-positive colorectal cancer liver-metastasis (CRLM; spread to the liver) undergoing surgery. Researchers suggested that surgery is associated with improved outcomes for these patients. Some background Colorectal cancer is one of the most common cancers in the US. Around 25% of...
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